Peter C. Fong, M.D., David S. Boss, M.Sc., Timothy A. Yap, M.D., Andrew Tutt, M.D., Ph.D., Peijun Wu, Ph.D., Marja Mergui-Roelvink, M.D., Peter Mortimer, Ph.D., Helen Swaisland, B.Sc., Alan Lau, Ph.D., Mark J. O'Connor, Ph.D., Alan Ashworth, Ph.D., James Carmichael, M.D., Stan B. Kaye, M.D., Jan H.M. Schellens, M.D., Ph.D., and Johann S. de Bono, M.D., Ph.D.
8 Jul 2009 | 5:00 pm
Background: The inhibition of poly(adenosine diphosphate [ADP]–ribose) polymerase (PARP) is a potential synthetic lethal therapeutic strategy for the treatment of cancers with specific DNA-repair defects, including those arising in carriers...